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COMPOUNDS / CANNABINOID / CBG
CANNABINOID

CBG

LOW RISK
BEST FOR:Neuropathic Pain●●●●●○○○○○5/10
CANNABIGEROL · CBG · CANNABIGEROL ISOLATE · CBG OIL
CannabinoidNon-psychoactivePhytocannabinoidNeuroprotectiveAnti-inflammatory

Non-psychoactive phytocannabinoid with potential anti-inflammatory, analgesic, and neuroprotective properties.

ROUTE / DOSAGE
LOW10mg
STANDARD20-50mg
HIGH100mg+
Note: Take with food to improve absorption
CYCLE
Daily use acceptable no established cycling requirement
BIOAVAILABILITY
~6% oral higher sublingual and inhaled
ACTIVE DURATION
4-8h (subjective)
STORAGE
Store in cool dry place away from direct light refrigerate oils and isolates to preserve potency
HALF-LIFE
6-8h (plasma)
DURATION BREAKDOWN
Total4-8h
Onset30-90min oral; 5-15min inhaled
Come up20-60min oral; 5-10min inhaled
Peak1-3h oral; 20-40min inhaled
Offset2-4h
After effects1-3h
Duration varies by route, dose, and individual. Source: community reports.
§ 01 — EFFECTS
6 documented
Non-psychoactive relaxation
Reduced neuropathic pain
Anti-inflammatory
Potential anxiolytic
Neuroprotective
No intoxication or cognitive impairment
§ 02 — RISKS
Drug interactions with CYP450 enzymes may alter metabolism of other medications
Limited human safety data; most evidence from preclinical models
May cause mild drowsiness or dry mouth at higher doses
Quality and purity of commercial CBG products varies widely
Potential false positive on cannabis drug tests depending on assay sensitivity
§ 03 — INTERACTIONS
No interaction with your stack
VIEW STACK
CAUTION
2C-T-x
2C-x
5-MeO-xxT
Amphetamines
aMT
Cocaine
DMT
DOx
LSD
Mescaline
Mushrooms
25x-NBOMe
AVOID · DANGEROUS
Lithium
§ 04 — SCIENCE

Preclinical studies in mice demonstrate CBG attenuates mechanical hypersensitivity in chemotherapy-induced peripheral neuropathy via CB1, CB2, and α2-adrenergic receptor mechanisms. A 2024 comprehensive review highlights potential applications in cancer, metabolic, pain, and inflammatory disorders. Pharmacokinetic data from mice show CBG is absorbed orally, intraperitoneally, and intravenously without producing intoxicating effects even at high concentrations. Human clinical trials remain scarce, and most evidence is from animal models or in vitro studies. CBG:CBD combinations may be more effective than CBG alone for neuropathic pain.

§ 06 — SOURCES
[1]
Cannabigerol (CBG): A Comprehensive Review of Its Molecular Mechanisms and Therapeutic Potential
pubmed.ncbi.nlm.nih.gov ↗
[2]
Cannabigerol (CBG) attenuates mechanical hypersensitivity elicited by chemotherapy-induced peripheral neuropathy
pubmed.ncbi.nlm.nih.gov ↗
[3]
Cannabigerol (CBG) signal enhancement in its analysis by gas chromatography coupled with tandem mass spectrometry
pubmed.ncbi.nlm.nih.gov ↗
[4]
Pharmacokinetics and pharmacodynamics of cannabigerol (CBG) in the C57BL/6Crl mouse
pubmed.ncbi.nlm.nih.gov ↗
[5]
PsychonautWiki - Cannabis
psychonautwiki.org ↗
Disclaimer. Protokol.wiki is an informational reference. Nothing on this site is medical advice. Compounds listed may be unapproved, unregulated, or illegal in your jurisdiction. Consult a licensed physician before use. Data compiled from peer-reviewed literature.
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