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COMPOUNDS / CANNABINOID / DOJA
CANNABINOID

DOJA

MEDIUM RISK
BEST FOR:Pain●●●●●●○○○○6/10
DOJA · CANNABIS · MARIJUANA · WEED · POT · HERB · THC · MARY JANE · CHRONIC
CannabinoidPsychoactivePainPlant-basedRecreational

Slang term for cannabis, a psychoactive plant containing THC and CBD that acts on cannabinoid receptors.

ROUTE / DOSAGE
LOW2.5mg
STANDARD5-10mg
HIGH20mg+
Note: Edibles have delayed onset and stronger effects - start low
CYCLE
No strict cycle tolerance builds with frequent use
BIOAVAILABILITY
inhalation: ~10-35% oral: ~4-12% (highly variable)
ACTIVE DURATION
inhalation: 2-4h oral: 4-8h (subjective)
STORAGE
Store in airtight opaque containers away from heat and light edibles refrigerated
HALF-LIFE
THC: 20-30h (chronic use longer) (plasma)
DURATION BREAKDOWN
Totalinhalation: 2-4h; oral: 4-8h
Onsetinhalation: seconds-minutes; oral: 30min-2h
Come upinhalation: 5-15min; oral: 30-60min
Peakinhalation: 10-30min; oral: 2-4h
Offsetinhalation: 1-2h; oral: 2-4h
After effects2-6h
Duration varies by route, dose, and individual. Source: community reports.
§ 01 — EFFECTS
6 documented
Euphoria and relaxation
Altered perception of time
Increased appetite
Dry mouth and red eyes
Impaired short-term memory
Anxiety or paranoia (dose-dependent)
§ 02 — RISKS
Psychosis risk in vulnerable individuals, especially with high-THC strains and adolescent use
Cannabis use disorder with chronic heavy use
Impaired driving ability and accident risk
Respiratory irritation from smoking (combustion)
Cognitive impairment with heavy long-term use
Drug interactions via CYP enzyme inhibition
§ 03 — INTERACTIONS
Interaction data not yet available for this compound.
§ 04 — SCIENCE

Cannabis contains over 100 cannabinoids, with THC being the primary psychoactive compound and CBD the primary non-intoxicating one. Evidence supports moderate efficacy for chronic pain, spasticity in multiple sclerosis, and chemotherapy-induced nausea. Evidence for anxiety and sleep disorders is mixed and of lower quality. Acute cognitive impairment is well-documented, and long-term heavy use is associated with risk of psychosis in vulnerable individuals, cognitive decline, and cannabis use disorder. Dose-response is biphasic for many effects, with low doses sometimes producing therapeutic benefit while higher doses exacerbate symptoms.

§ 06 — SOURCES
[1]
PubMed PMID 36971587
pubmed.ncbi.nlm.nih.gov ↗
[2]
PubMed PMID 33150406
pubmed.ncbi.nlm.nih.gov ↗
[3]
PubMed PMID 36424917
pubmed.ncbi.nlm.nih.gov ↗
[4]
PubMed PMID 37021289
pubmed.ncbi.nlm.nih.gov ↗
[5]
PubMed PMID 40811633
pubmed.ncbi.nlm.nih.gov ↗
[6]
PubMed PMID 41526342
pubmed.ncbi.nlm.nih.gov ↗
[7]
PubMed PMID 39442038
pubmed.ncbi.nlm.nih.gov ↗
[8]
PubMed PMID 37586838
pubmed.ncbi.nlm.nih.gov ↗
Disclaimer. Protokol.wiki is an informational reference. Nothing on this site is medical advice. Compounds listed may be unapproved, unregulated, or illegal in your jurisdiction. Consult a licensed physician before use. Data compiled from peer-reviewed literature.
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