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COMPOUNDS / LONGEVITY / EGCG
LONGEVITY

EGCG

LOW RISK
BEST FOR:Antioxidant●●●●●●●○○○7/10
EGCG · EPIGALLOCATECHIN GALLATE · EPIGALLOCATECHIN-3-GALLATE · (-)-EPIGALLOCATECHIN-3-GALLATE · EPI-GALLOCATECHIN GALLATE · EGCG
AntioxidantPolyphenolGreen teaLongevityAnti-inflammatoryNeuroprotective

Most abundant catechin in green tea; potent antioxidant with anti-inflammatory, anticancer, and neuroprotective properties.

ROUTE / DOSAGE
LOW100mg
STANDARD200-400mg
HIGH800mg
Note: Take between meals for absorption; avoid exceeding 800mg/day due to hepatotoxicity risk
CYCLE
Daily use acceptable up to 400mg cycle off after 8-12 weeks
BIOAVAILABILITY
~0.2-2% oral (fasted state) significantly higher sublingual
ACTIVE DURATION
4-8h (subjective)
STORAGE
Room temperature dry away from light protect from moisture and oxygen to prevent degradation
HALF-LIFE
1.5-3.6h (plasma)
DURATION BREAKDOWN
Total4-8h
Onset1-2h
Come up1-2h
Peak2-3h
Offset3-5h
After effectsminimal
Duration varies by route, dose, and individual. Source: community reports.
§ 01 — EFFECTS
8 documented
Potent antioxidant activity
Anti-inflammatory via NF-κB inhibition
Promotes autophagy via AMPK/ULK1
Neuroprotective against oxidative stress
Modulates epigenetic markers
Anti-proliferative in cancer models
Supports cardiovascular health
Promotes wound healing
§ 02 — RISKS
Hepatotoxicity reported at high doses (>800mg/day) with green tea extracts
Gastrointestinal upset including nausea and diarrhea
May inhibit CYP enzymes and alter drug metabolism
Iron chelation may reduce iron absorption
Caffeine content in crude extracts may cause insomnia or palpitations
§ 03 — INTERACTIONS
Interaction data not yet available for this compound.
§ 04 — SCIENCE

EGCG is the most studied catechin in green tea, with extensive in vitro and animal data demonstrating antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. Human clinical trials have shown modest benefits for cardiovascular health, weight management, and cognitive function, though effect sizes are typically small. Oral bioavailability is notoriously low (~0.2-2% in humans), which limits clinical translation and has driven interest in nanoparticle and esterification delivery strategies. Hepatotoxicity has been reported with high-dose green tea extract supplements, prompting regulatory reviews in several countries. Evidence for anticancer and wound-healing applications remains primarily preclinical.

§ 06 — SOURCES
[1]
EGCG-based nanoparticles: synthesis, properties, and applications
pubmed.ncbi.nlm.nih.gov ↗
[2]
The Epigenetic Modification of Epigallocatechin Gallate (EGCG) on Cancer
pubmed.ncbi.nlm.nih.gov ↗
[3]
Comprehensive Review of EGCG Modification: Esterification Methods and Their Impacts on Biological Activities
pubmed.ncbi.nlm.nih.gov ↗
[4]
Targeting Cancer Hallmarks with Epigallocatechin Gallate (EGCG): Mechanistic Basis and Therapeutic Targets
pubmed.ncbi.nlm.nih.gov ↗
[5]
EGCG Restores Keratinocyte Autophagy to Promote Diabetic Wound Healing through the AMPK/ULK1 Pathway
pubmed.ncbi.nlm.nih.gov ↗
[6]
Research progress in biological activities and oocyte aging-regulating effect of EGCG
pubmed.ncbi.nlm.nih.gov ↗
[7]
L-EGCG-Mn nanoparticles as a pH-sensitive MRI contrast agent
pubmed.ncbi.nlm.nih.gov ↗
[8]
EGCG treats ICH via up-regulating miR-137-3p and inhibiting Parthanatos
pubmed.ncbi.nlm.nih.gov ↗
Disclaimer. Protokol.wiki is an informational reference. Nothing on this site is medical advice. Compounds listed may be unapproved, unregulated, or illegal in your jurisdiction. Consult a licensed physician before use. Data compiled from peer-reviewed literature.
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