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COMPOUNDS / CANNABINOID / CBN
CANNABINOID

CBN

LOW RISK
BEST FOR:Sleep●●●●●○○○○○5/10
CANNABINOL · CBN · CANNABINOL ISOLATE
CannabinoidSleep AidNeuroprotectantAntioxidantPhytocannabinoid

A mildly psychoactive phytocannabinoid and THC degradation product studied for sleep, neuroprotection, and anti-inflammatory effects.

ROUTE / DOSAGE
LOW5mg
STANDARD10-20mg
HIGH50mg+
Note: CUPID trial used 30mg and 300mg single doses for insomnia
CYCLE
As needed for sleep no established cycling protocol
BIOAVAILABILITY
~6-10% oral ~15-20% sublingual ~30-50% inhaled
ACTIVE DURATION
4-8h oral 2-4h inhaled (subjective)
STORAGE
Room temperature dry away from light store in airtight container to prevent further oxidation
HALF-LIFE
2-6h (plasma)
DURATION BREAKDOWN
Total4-8h oral, 2-4h inhaled
Onset30-90min oral, 1-10min inhaled, 5-15min sublingual
Come up30-60min oral, 5-10min inhaled, 15-30min sublingual
Peak2-4h oral, 30-60min inhaled
Offset2-4h
After effects2-6h
Duration varies by route, dose, and individual. Source: community reports.
§ 01 — EFFECTS
6 documented
Sedation and sleepiness
Mild psychoactive effects (far less than THC)
Anti-inflammatory
Neuroprotective and antioxidant
Potential appetite stimulation
Relaxation
§ 02 — RISKS
Developmental toxicity demonstrated in zebrafish via CB2 receptor mechanisms
Drowsiness and impairment of next-day function
Potential psychoactive effects at high doses
Drug interactions via cannabinoid receptor modulation
Lack of human clinical safety data for chronic use
§ 03 — INTERACTIONS
No interaction with your stack
VIEW STACK
CAUTION
2C-T-x
2C-x
5-MeO-xxT
Amphetamines
aMT
Cocaine
DMT
DOx
LSD
Mescaline
Mushrooms
25x-NBOMe
AVOID · DANGEROUS
Lithium
§ 04 — SCIENCE

CBN is the primary oxidative degradation product of THC and is found in aged cannabis. Preclinical evidence from the SAMP8 mouse model shows CBN improves spatial learning and memory, with sex-specific metabolic benefits, by modulating mitochondrial dynamics and upregulating synaptic proteins. A zebrafish study demonstrated that CBN exposure during gastrulation causes dose-dependent developmental defects via CB2 receptor-mediated mechanisms, raising safety concerns for prenatal exposure. A human proof-of-concept trial (CUPID) is investigating 30mg and 300mg oral CBN for insomnia using polysomnography, but results have not yet been published. Evidence for CBN as a standalone sleep aid remains largely anecdotal and preclinical; robust human clinical data are lacking.

§ 06 — SOURCES
[1]
Cannabinol (CBN) alleviates age-related cognitive decline by improving synaptic and mitochondrial health
pubmed.ncbi.nlm.nih.gov ↗
[2]
Skin-Whitening Effects of Cannabinol (CBN) Through Melanin Inhibition in B16F10 Melanoma Cells
pubmed.ncbi.nlm.nih.gov ↗
[3]
Cannabinol (CBN; 30 and 300 mg) effects on sleep and next-day function in insomnia disorder (CUPID study protocol)
pubmed.ncbi.nlm.nih.gov ↗
[4]
Cannabinoid receptor 2 (Cb2r) mediates cannabinol (CBN) induced developmental defects in zebrafish
pubmed.ncbi.nlm.nih.gov ↗
[5]
PsychonautWiki - Cannabis
psychonautwiki.org ↗
Disclaimer. Protokol.wiki is an informational reference. Nothing on this site is medical advice. Compounds listed may be unapproved, unregulated, or illegal in your jurisdiction. Consult a licensed physician before use. Data compiled from peer-reviewed literature.
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