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COMPOUNDS / CANNABINOID / WEED
CANNABINOID

WEED

MEDIUM RISK
BEST FOR:Pain Relief●●●●●●●○○○7/10
CANNABIS · MARIJUANA · WEED · POT · GRASS · HERB · GANJA · DAGGA · THC · MARY JANE · BUD · FLOWER
CannabinoidPsychoactivePhytocannabinoidPain ReliefSchedule I

Psychoactive plant containing THC and CBD; acts on CB1/CB2 receptors producing euphoria, relaxation, and altered perception.

ROUTE / DOSAGE
LOW2.5mg
STANDARD5-10mg
HIGH25mg+
Note: THC dose; onset delayed 30-120min. Edibles can be unpredictable - start low.
CYCLE
No established cycle tolerance builds with frequent use
BIOAVAILABILITY
inhalation ~10-35% oral 4-12% (highly variable) sublingual ~15-25%
ACTIVE DURATION
inhalation 2-4h oral 4-8h (subjective)
STORAGE
Store in airtight opaque containers away from light and heat refrigeration for concentrates and edibles
HALF-LIFE
THC: 20-30h (chronic use up to 3-5 days) (plasma)
DURATION BREAKDOWN
Totalinhalation 2-4h; oral 4-8h
Onsetinhalation: seconds-10min; oral: 30-120min
Come upinhalation 5-10min; oral 30-60min
Peakinhalation 20-60min; oral 2-3h
Offsetinhalation 1-2h; oral 2-4h
After effects2-6h
Duration varies by route, dose, and individual. Source: community reports.
§ 01 — EFFECTS
8 documented
Euphoria and elevated mood
Relaxation and sedation
Altered sensory perception
Increased appetite
Impaired short-term memory
Time distortion
Dry mouth and red eyes
Anxiety or paranoia at high doses
§ 02 — RISKS
Cannabis use disorder develops in ~9% of users, ~17% of those starting in adolescence
Increased risk of psychosis and schizophrenia in vulnerable individuals, especially with high-THC strains and adolescent use
Impaired driving ability and increased accident risk
Cognitive deficits in attention and memory with heavy use, partially persisting after cessation
Respiratory irritation from smoking; possible link to chronic bronchitis
Hyperemesis syndrome (CHS) with chronic heavy use
§ 03 — INTERACTIONS
No interaction with your stack
VIEW STACK
CAUTION
2C-T-x
2C-x
5-MeO-xxT
Amphetamines
aMT
Cocaine
DMT
DOx
LSD
Mescaline
Mushrooms
25x-NBOMe
AVOID · DANGEROUS
Lithium
§ 04 — SCIENCE

Cannabis has substantial evidence for chronic pain, chemotherapy-induced nausea, and spasticity in multiple sclerosis. Evidence for anxiety and PTSD treatment is mixed and dose-dependent. Cognitive impairment with heavy or adolescent use is well-documented. The risk-benefit ratio depends heavily on THC:CBD ratio, route, dose, and individual factors. Long-term safety data remains limited for many indications.

§ 06 — SOURCES
[1]
PsychonautWiki - Cannabis
psychonautwiki.org ↗
Disclaimer. Protokol.wiki is an informational reference. Nothing on this site is medical advice. Compounds listed may be unapproved, unregulated, or illegal in your jurisdiction. Consult a licensed physician before use. Data compiled from peer-reviewed literature.
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