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COMPOUNDS / ADAPTOGEN / PASSIONFLOWER
ADAPTOGEN

PASSIONFLOWER

LOW RISK
BEST FOR:Anxiety & Sleep●●●●●●○○○○6/10
PASSIONFLOWER · PASSIFLORA INCARNATA · PASSIFLORA · MAYPOP · PASSION VINE · APRICOT VINE · MARACUJA · FLEUR DE LA PASSION
AnxiolyticSleep aidHerbal medicineGABAergicFlavonoidTraditional remedy

Traditional herbal anxiolytic and sleep aid with GABAergic flavonoids, used for mild anxiety and insomnia.

ROUTE / DOSAGE
LOW300mg
STANDARD400-500mg
HIGH900mg
Note: Extract standardized to flavonoids; tea form uses 1-2g dried herb per cup
CYCLE
Daily use acceptable for short-term (2-4 weeks) no strict cycling required
BIOAVAILABILITY
Low-moderate oral (~30-40% for key flavonoids) chrysin bioavailability notably low (~5%) due to extensive first-pass metabolism
ACTIVE DURATION
4-6h (subjective)
STORAGE
Store in cool dry place away from direct light keep extracts and tinctures tightly sealed
HALF-LIFE
2-4h (plasma)
DURATION BREAKDOWN
Total4-6h
Onset30min-2h
Come up30-60 min
Peak1-2h
Offset2-3h
After effects1-2h
Duration varies by route, dose, and individual. Source: community reports.
§ 01 — EFFECTS
6 documented
Reduced anxiety and nervous tension
Improved sleep quality and total sleep time
Mild sedation without significant cognitive impairment
Muscle relaxation
Mood stabilization
Low incidence of daytime drowsiness
§ 02 — RISKS
May potentiate effects of sedatives, benzodiazepines, and other CNS depressants
Mild MAO-A inhibition may interact with serotonergic medications
Drowsiness or dizziness at higher doses
Product quality varies widely - many food supplements fail identity and content testing
Pregnancy and lactation safety not established
§ 03 — INTERACTIONS
Interaction data not yet available for this compound.
§ 04 — SCIENCE

A double-blind RCT found passionflower extract comparable to oxazepam for generalized anxiety disorder with fewer job-performance impairments. A placebo-controlled study demonstrated improved subjective sleep quality with passionflower tea in healthy adults. A polysomnography study showed significantly increased total sleep time in insomnia patients after 2 weeks of passionflower extract. A systematic review of 9 clinical trials reported reduced anxiety levels with no adverse effects on cognitive function. However, most trials are small and short-term; large-scale studies are lacking. Product quality varies significantly, with analytical testing revealing that many food supplements fail to meet identity and content specifications.

§ 06 — SOURCES
[1]
Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam
pubmed.ncbi.nlm.nih.gov ↗
[2]
A double-blind, placebo-controlled investigation of the effects of Passiflora incarnata herbal tea on subjective sleep quality
pubmed.ncbi.nlm.nih.gov ↗
[3]
Passiflora incarnata in Neuropsychiatric Disorders - A Systematic Review
pubmed.ncbi.nlm.nih.gov ↗
[4]
Saffron, passionflower, valerian and sage for mental health
pubmed.ncbi.nlm.nih.gov ↗
[5]
Herbal Medicinal Products from Passiflora for Anxiety: An Unexploited Potential
pubmed.ncbi.nlm.nih.gov ↗
[6]
Effects of Passiflora incarnata Linnaeus on polysomnographic sleep parameters in subjects with insomnia disorder
pubmed.ncbi.nlm.nih.gov ↗
[7]
Passionflower (French article)
pubmed.ncbi.nlm.nih.gov ↗
[8]
Passionflower (Passiflora incarnata): Quality of Food Supplements Versus Registered Herbal Medicinal Products
pubmed.ncbi.nlm.nih.gov ↗
Disclaimer. Protokol.wiki is an informational reference. Nothing on this site is medical advice. Compounds listed may be unapproved, unregulated, or illegal in your jurisdiction. Consult a licensed physician before use. Data compiled from peer-reviewed literature.
METHODOLOGYCONTRIBUTECONTACT