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COMPOUNDS / ADAPTOGEN / CHILCUAGUE
ADAPTOGEN

CHILCUAGUE

LOW RISK
BEST FOR:Pain relief●●●●●○○○○○5/10
CHILCUAGUE · HELIOPSIS LONGIPES · AFFININ · HELIOPSIS LONGIPES ROOT EXTRACT · CHILCAGUÁN · AGÜECHIN · PELITRE DE LA SIERRA
Mexican traditional medicineAlkamideAnalgesicBotanicalVasodilator

Mexican medicinal plant (Heliopsis longipes) whose root alkamides provide analgesic, stimulant, and vasodilatory effects.

ROUTE / DOSAGE
LOW250mg
STANDARD500-1000mg
HIGH1500mg+
Note: Root extract or powder; traditional preparation as decoction also common
CYCLE
As needed for pain no established daily dosing protocol
BIOAVAILABILITY
Low oral (~10-20%) higher sublingual (~40-60%) due to mucosal absorption bypassing first-pass metabolism
ACTIVE DURATION
2-4h (subjective)
STORAGE
Store dried root or extract in airtight container away from light and moisture at room temperature
DURATION BREAKDOWN
Total2-4h
Onset5-30min
Come up10-20min
Peak1-2h
Offset1-2h
After effects1-2h
Duration varies by route, dose, and individual. Source: community reports.
§ 01 — EFFECTS
6 documented
Analgesia comparable to NSAIDs
CNS stimulation similar to caffeine
Local numbing and tingling sensation
Vasodilation
Proangiogenic activity
Antiparasitic (traditional use)
§ 02 — RISKS
Allergic reactions possible with Asteraceae family sensitivity
Intense mucosal irritation and tingling with sublingual use
Lack of human safety data limits established dosing
Potential drug interactions with NSAIDs or caffeine-containing products
Variable alkamide content depending on plant phenological stage
§ 03 — INTERACTIONS
Interaction data not yet available for this compound.
§ 04 — SCIENCE

Three published studies confirm bioactivity of Heliopsis longipes root and its main alkamide affinin. Cilia-López et al. (2010) demonstrated analgesic activity comparable to ketorolac and CNS stimulation comparable to caffeine in mouse models. García-Badillo et al. (2021) showed dose-dependent proangiogenic effects of affinin and ethanolic root extract both ex vivo and in vivo. Ruiz-Castillo et al.) characterized the alkamide profile across phenological stages, finding that vasodilatory activity peaks during fructification. Evidence is limited to preclinical animal and ex vivo models; no human clinical trials have been published. Traditional use in Mexican medicine for dental and muscle pain spans centuries but lacks formal pharmacokinetic characterization in humans.

§ 06 — SOURCES
[1]
PubMed PMID 20645840 - Analgesic activity of Heliopsis longipes and its effect on the nervous system
pubmed.ncbi.nlm.nih.gov ↗
[2]
PubMed PMID 42357510 - Metabolomic Analysis of Heliopsis longipes Roots Across Phenological Stages
pubmed.ncbi.nlm.nih.gov ↗
[3]
PubMed PMID 34946751 - Proangiogenic Effect of Affinin and an Ethanolic Extract from Heliopsis longipes Roots
pubmed.ncbi.nlm.nih.gov ↗
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