PROTOKOLwiki
COMPOUNDS / GABAERGIC / PHENIBUT
GABAERGIC

PHENIBUT

HIGH RISK
BEST FOR:Anxiety●●●●●●●●●●10/10
PHENIBUT · Β-PHENYL-Γ-AMINOBUTYRIC ACID · BETA-PHENYL-GABA · FENIBUT · NOOFEN · ANVIFEN · PHENIBUT HCL
GABAergicAnxiolyticNootropicSoviet / RussianDependence Risk

GABA(B) agonist developed in Russia as an anxiolytic and nootropic; unregulated supplement with high dependence and withdrawal risk.

ROUTE / DOSAGE
LOW200-500mg
STANDARD700-1000mg
HIGH2000mg+
Note: Take on empty stomach for faster onset; effects can take 2-4 hours to manifest
CYCLE
no daily use!
BIOAVAILABILITY
~63% oral
ACTIVE DURATION
10-14h (subjective)
STORAGE
Room temperature dry away from light
HALF-LIFE
5-6h (plasma)
DURATION BREAKDOWN
Total10-14h
Onset1.5-3h
Come up1.5-3h
Peak2-4h
Offset4-6h
After effects6-12h
Duration varies by route, dose, and individual. Source: community reports.
§ 01 — EFFECTS
6 documented
Anxiolysis
Nootropic cognitive enhancement
Sedation
Sleep improvement
Tension and fear relief
Mood elevation
§ 02 — RISKS
Physical dependence and addiction
Severe withdrawal including delirium, hallucinations, and seizures
Acute intoxication requiring hospitalization and intubation
Altered mental status and psychosis
Polysubstance use complications (benzodiazepines, alcohol)
§ 03 — INTERACTIONS
Interaction data not yet available for this compound.
§ 04 — SCIENCE

Multiple systematic reviews have documented phenibut toxicity and withdrawal from case reports and case series, with no controlled clinical trials available. Across 62 identified cases, 80.7% were male with a mean age of 30.9 years, and 63.2% involved concomitant substance use. Intoxication cases required intubation in 48.7% of cases, and withdrawal cases frequently required multiple medications including benzodiazepines, baclofen, and barbiturates. Evidence is limited to case reports subject to publication bias, and no standardized treatment protocols exist. Doses reported in the literature range from 1.5 g/day to 200 g/day, reflecting unregulated use patterns rather than established therapeutic dosing.

§ 06 — SOURCES
[1]
Phenibut: A drug with one too many "buts" — PMID 39197876
pubmed.ncbi.nlm.nih.gov ↗
[2]
Phenibut: Review and Pharmacologic Approaches to Treating Withdrawal — PMID 38339875
pubmed.ncbi.nlm.nih.gov ↗
[3]
A Systematic Review of Phenibut Withdrawals — PMID 39376891
pubmed.ncbi.nlm.nih.gov ↗
[4]
Phenibut (β-Phenyl-γ-Aminobutyric Acid): an Easily Obtainable "Dietary Supplement" With Propensities for Physical Dependence and Addiction — PMID 30852710
pubmed.ncbi.nlm.nih.gov ↗
[5]
Clinical Presentations and Treatment of Phenibut Toxicity and Withdrawal: A Systematic Literature Review — PMID 37579098
pubmed.ncbi.nlm.nih.gov ↗
[6]
A systematic review of phenibut withdrawal focusing on complications, therapeutic approaches, and single substance versus polysubstance withdrawal — PMID 38112312
pubmed.ncbi.nlm.nih.gov ↗
[7]
Phenibut overdose — PMID 27666756
pubmed.ncbi.nlm.nih.gov ↗
[8]
Phenibut (beta-phenyl-GABA): a tranquilizer and nootropic drug — PMID 11830761
pubmed.ncbi.nlm.nih.gov ↗
Disclaimer. Protokol.wiki is an informational reference. Nothing on this site is medical advice. Compounds listed may be unapproved, unregulated, or illegal in your jurisdiction. Consult a licensed physician before use. Data compiled from peer-reviewed literature.
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