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COMPOUNDS / NOOTROPIC / VINPOCETINE
NOOTROPIC

VINPOCETINE

LOW RISK
BEST FOR:Cognition●●●●○○○○○○4/10
VINPOCETINE · CAVINTON · ETHYL APOVINCAMINATE · RGH-8737 · ETHYL APOVINCAMINATE · VINPOCETINUM
NootropicVasodilatorAntioxidantCerebrovascularPDE1 InhibitorPeriwinkle derivative

Synthetic vincamine derivative used as a nootropic for cerebral blood flow enhancement and neuroprotection.

ROUTE / DOSAGE
LOW5mg
STANDARD10-20mg
HIGH40mg+
Note: Typically dosed 5-10mg two to three times daily with meals to improve absorption
CYCLE
Daily use 2-3x per day
BIOAVAILABILITY
low oral (~6-7%)
ACTIVE DURATION
2-4h (subjective)
STORAGE
Room temperature dry away from light
DURATION BREAKDOWN
Total3-6 hours
Onset30min-1h
Come up30-60 min
Peak1-2 hours
Offset1-2 hours
After effects2-4 hours
Duration varies by route, dose, and individual. Source: community reports.
§ 01 — EFFECTS
8 documented
Enhanced cerebral blood flow
Mild cognitive support
Neuroprotective against oxidative stress
Anti-inflammatory via NF-κB inhibition
Antioxidant via Nrf2/GPX4 activation
Potential anti-ferroptosis activity
Atheroprotective effects
Generally well tolerated
§ 02 — RISKS
Contraindicated in pregnancy due to potential uterine bleeding
May lower blood pressure causing hypotension
Gastrointestinal upset and nausea reported
Headache and dizziness at higher doses
Potential skin rash or hypersensitivity
FDA does not recognize vinpocetine as a dietary ingredient in the US
§ 03 — INTERACTIONS
Interaction data not yet available for this compound.
§ 04 — SCIENCE

Vinpocetine has been used clinically in several countries for cerebrovascular disorders and cognitive enhancement. A Cochrane review found insufficient evidence to evaluate its efficacy in acute ischemic stroke, with only two small trials involving 70 participants total. A double-blind crossover study in healthy volunteers and epilepsy patients found no significant cognitive benefits at single doses of 10-60mg, though blood levels were substantially lower than those showing efficacy in animal models. Recent preclinical research has explored its potential in osteoarthritis through inhibition of ferroptosis and extracellular matrix degradation via the Nrf2/GPX4 pathway. Its anti-inflammatory and antioxidant properties have also demonstrated atheroprotective potential in narrative reviews. Evidence for cognitive enhancement in healthy humans remains weak, with most positive findings limited to animal studies or clinical use in cerebrovascular disease.

§ 06 — SOURCES
[1]
PubMed PMID 39368343
pubmed.ncbi.nlm.nih.gov ↗
[2]
PubMed PMID 35396012
pubmed.ncbi.nlm.nih.gov ↗
[3]
PubMed PMID 12126465
pubmed.ncbi.nlm.nih.gov ↗
[4]
PubMed PMID 32608268
pubmed.ncbi.nlm.nih.gov ↗
[5]
PubMed PMID 33957389
pubmed.ncbi.nlm.nih.gov ↗
[6]
PubMed PMID 18253980
pubmed.ncbi.nlm.nih.gov ↗
[7]
PubMed PMID 10796369
pubmed.ncbi.nlm.nih.gov ↗
[8]
PubMed PMID 39141151
pubmed.ncbi.nlm.nih.gov ↗
Disclaimer. Protokol.wiki is an informational reference. Nothing on this site is medical advice. Compounds listed may be unapproved, unregulated, or illegal in your jurisdiction. Consult a licensed physician before use. Data compiled from peer-reviewed literature.
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