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COMPOUNDS / PSYCHEDELIC / SALVIA
PSYCHEDELIC

SALVIA

HIGH RISK
BEST FOR:Exploratory●●○○○○○○○○2/10
SALVIA DIVINORUM · SALVINORIN A · SAGE OF THE DIVINERS · SEER'S SAGE · SKA MARIA PASTORA · LADY SALVIA · DIVINER'S SAGE
PsychedelicKappa-OpioidDissociativeEntheogenicShort-ActingPlant-Based

Potent short-acting kappa-opioid agonist psychedelic from Salvia divinorum, producing intense dissociative visions.

ROUTE / DOSAGE
LOW200mcg
STANDARD500-1000mcg
HIGH2000mcg+
Note: Quid method - chewed leaves held in mouth; GI metabolism renders swallowing ineffective
CYCLE
Max 1x per week no daily use
BIOAVAILABILITY
low oral (~3%) high inhalation
ACTIVE DURATION
15-60 min (subjective)
STORAGE
Room temperature dry away from light store dried leaves and extracts in airtight containers
HALF-LIFE
1-2h (plasma)
DURATION BREAKDOWN
Total15-90 min
Onset15-60 sec (inhalation); 10-20 min (sublingual)
Come up1-5 min
Peak5-20 min
Offset5-15 min
After effects30-60 min
Duration varies by route, dose, and individual. Source: community reports.
§ 01 — EFFECTS
8 documented
Intense short-lived visual and auditory hallucinations
Dissociation from body and environment
Altered perception of space and time
Loss of physical coordination
Uncontrollable laughter or dysphoria
Rapid onset and short duration when smoked
Profound changes in self-awareness
Potential for overwhelming or frightening experiences
§ 02 — RISKS
Risk of psychological distress, panic, and traumatic experiences during intense trips
Loss of physical coordination leading to injury during the experience
Potential for persistent derealization or depersonalization in susceptible individuals
Risk of accidental harm due to rapid onset and loss of awareness while standing or moving
Limited research on long-term psychiatric effects with repeated use
Potential for KOR-mediated dysphoric reactions and aversive emotional states
§ 03 — INTERACTIONS
Interaction data not yet available for this compound.
§ 04 — SCIENCE

Salvinorin A is the active psychoactive compound in Salvia divinorum, a plant traditionally used by Mazatec shamans in Oaxaca, Mexico. It is one of the most potent naturally occurring psychedelics, active at sub-milligram doses when smoked. Human and animal studies confirm its KOR-mediated mechanism, which is distinct from serotonergic psychedelics. Clinical research on Salvia divinorum is extremely limited, with most data coming from anecdotal reports and surveys. The broader Salvia genus (S. officinalis, S. miltiorrhiza) has been studied for cognitive, cardiovascular, and anticancer properties, but these involve different active compounds and are not applicable to S. divinorum. Evidence on long-term effects, addiction potential, and therapeutic applications remains weak and preliminary.

§ 06 — SOURCES
[1]
PsychonautWiki - Salvinorin A
psychonautwiki.org ↗
[2]
PubMed PMID 27888449 - Salvia (Sage): A Review of its Potential Cognitive-Enhancing and Protective Effects
pubmed.ncbi.nlm.nih.gov ↗
[3]
PubMed PMID 33373790 - Iranian Salvia species: A phytochemical and pharmacological update
pubmed.ncbi.nlm.nih.gov ↗
[4]
PubMed PMID 40997663 - Research progress on the pharmacological properties of active ingredients from Salvia miltiorrhiza
pubmed.ncbi.nlm.nih.gov ↗
Disclaimer. Protokol.wiki is an informational reference. Nothing on this site is medical advice. Compounds listed may be unapproved, unregulated, or illegal in your jurisdiction. Consult a licensed physician before use. Data compiled from peer-reviewed literature.
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