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COMPOUNDS / PSYCHEDELIC / PEYOTE
PSYCHEDELIC

PEYOTE

MEDIUM RISK
BEST FOR:Mood●●●●●○○○○○5/10
PEYOTE · LOPHOPHORA WILLIAMSII · MESCALINE CACTUS · PEYOTE BUTTONS · PÉYOTL · HÍKURI
PsychedelicEntheogenicCactusNative AmericanClassical

Small spineless cactus containing mescaline, a long-lasting classical psychedelic used for millennia in Indigenous ceremonies.

ROUTE / DOSAGE
LOW50-200mg
STANDARD200-400mg
HIGH400-800mg
Note: Doses refer to mescaline content; fresh peyote buttons contain ~3-6% mescaline by dry weight
CYCLE
Max once per week tolerance builds rapidly 3-7 day reset period
BIOAVAILABILITY
Moderate oral (~30-50%)
ACTIVE DURATION
8-14h (subjective)
STORAGE
Fresh cactus: cool dry place away from direct sunlight. Dried buttons: airtight container room temperature away from light and moisture
HALF-LIFE
~6 hours (plasma)
DURATION BREAKDOWN
Total8-14 hours
Onset45-90 min
Come up1-2 hours
Peak2-4 hours
Offset3-5 hours
After effects4-8 hours
Duration varies by route, dose, and individual. Source: community reports.
§ 01 — EFFECTS
7 documented
Geometric visual hallucinations
Altered perception of time and space
Euphoria and enhanced well-being
Synesthesia
Nausea and vomiting during onset
Spiritual and mystical experiences
Increased empathy and introspection
§ 02 — RISKS
Nausea and vomiting during onset (very common)
Psychotomimetic effects in vulnerable individuals
Potential teratogenic effects if used during pregnancy
Prolonged 8-14 hour duration may cause physical and mental exhaustion
Risk of HPPD with repeated use
Sympathomimetic effects including elevated heart rate and blood pressure
§ 03 — INTERACTIONS
No interaction with your stack
VIEW STACK
CAUTION
5-MeO-xxT
Cannabis
Amphetamines
Cocaine
MAOIs
AVOID · DANGEROUS
ΑMT
Tramadol
§ 04 — SCIENCE

Mescaline has been used for over 5,700 years in Indigenous ceremonial contexts, with modern research confirming its 5-HT2A agonist mechanism shared with other classical psychedelics. Clinical observations suggest potential benefits for alcoholism and mental health conditions, though controlled trials remain scarce due to scheduling restrictions. Animal studies show anxiolytic-like effects and increased prosocial behaviour. Most intoxications are mild and self-limiting, with addiction and dependence being practically absent. Evidence for therapeutic use is largely observational and naturalistic rather than from randomized controlled trials.

§ 06 — SOURCES
[1]
PubMed PMID 38138432 - Overview on Hallucinogenic Peyote and Mescaline
pubmed.ncbi.nlm.nih.gov ↗
[2]
PubMed PMID 36252614 - Mescaline: The Forgotten Psychedelic
pubmed.ncbi.nlm.nih.gov ↗
[3]
PubMed PMID 30318013 - Pharmacokinetic and Pharmacodynamic Aspects of Peyote and Mescaline
pubmed.ncbi.nlm.nih.gov ↗
[4]
PubMed PMID 11211421 - Peyote Use During Pregnancy
pubmed.ncbi.nlm.nih.gov ↗
[5]
PubMed PMID 37675639 - Elucidation of Mescaline Biosynthetic Pathway in Peyote
pubmed.ncbi.nlm.nih.gov ↗
[6]
PsychonautWiki - Mescaline
psychonautwiki.org ↗
Disclaimer. Protokol.wiki is an informational reference. Nothing on this site is medical advice. Compounds listed may be unapproved, unregulated, or illegal in your jurisdiction. Consult a licensed physician before use. Data compiled from peer-reviewed literature.
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