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COMPOUNDS / NOOTROPIC / PANTOCALCIN
NOOTROPIC

PANTOCALCIN

LOW RISK
BEST FOR:Cognition●●●●●●○○○○6/10
PANTOCALCIN · HOPANTENIC ACID · PANTOGAM · GOPANTENIC ACID · CALCIUM HOPANTENATE · PANTOGAM ACTIV
NootropicGABAergicSoviet / RussianPediatricNeuroprotectiveCholinergic

A Russian nootropic derived from pantothenic acid with GABAergic and neuroprotective properties, used for pediatric neurological disorders.

ROUTE / DOSAGE
LOW250mg
STANDARD500-1000mg
HIGH1500mg
Note: Typically divided into 2 doses daily; pediatric doses are lower and weight-based
CYCLE
1-3 months continuous use reassess before extending
BIOAVAILABILITY
moderate oral (~40-60%)
ACTIVE DURATION
4-8h (subjective)
STORAGE
Room temperature dry away from light
HALF-LIFE
6.7h (plasma)
DURATION BREAKDOWN
Total8-12h
Onset30min-1.5h
Come up30-90 min
Peak1-3h
Offset3-6h
After effects2-6h
Duration varies by route, dose, and individual. Source: community reports.
§ 01 — EFFECTS
6 documented
Improved attention and concentration
Enhanced visual memory
Reduced anxiety
Neuroprotective support
Cognitive stabilization in pediatric neurological disorders
Mild sedative effect
§ 02 — RISKS
Allergic reactions in sensitive individuals
Possible sedation or drowsiness
Insufficient international safety data
Limited evidence outside pediatric Russian populations
§ 03 — INTERACTIONS
Interaction data not yet available for this compound.
§ 04 — SCIENCE

Pantocalcin has been studied primarily in Russian clinical trials for pediatric neurological conditions including cerebral palsy, ADHD, cognitive disorders, and perinatal CNS lesions. A randomized study in children with cerebral palsy showed improvements in visual memory, attention concentration, and reduced anxiety, though no effect on visual-motor skills was observed. Pharmacokinetic data from 18 healthy volunteers confirms oral bioavailability with peak plasma levels at 1.56 hours and elimination half-life of 6.68 hours. The evidence base is largely confined to Russian-language publications and lacks large-scale international replication, limiting generalizability of findings.

§ 06 — SOURCES
[1]
Modern application possibilities hopanthenic acid (Pantocalcin) in treatment diseases of the nervous system in children
pubmed.ncbi.nlm.nih.gov ↗
[2]
Management of cognitive impairment in children and adolescents with cerebral palsy treated with pantocalcin
pubmed.ncbi.nlm.nih.gov ↗
[3]
Pharmacokinetics of hopantenic acid upon peroral administration
pubmed.ncbi.nlm.nih.gov ↗
Disclaimer. Protokol.wiki is an informational reference. Nothing on this site is medical advice. Compounds listed may be unapproved, unregulated, or illegal in your jurisdiction. Consult a licensed physician before use. Data compiled from peer-reviewed literature.
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