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COMPOUNDS / PSYCHEDELIC / LSD
PSYCHEDELIC

LSD

MEDIUM RISK
BEST FOR:Psychotherapy●●●●●○○○○○5/10
LSD · LYSERGIC ACID DIETHYLAMIDE · ACID · LSD-25 · LYSERGIDE · D-LSD · N,N-DIETHYLLYSERGAMIDE
PsychedelicClassicalSerotonergicHallucinogen5-HT2A

A potent serotonergic hallucinogen that alters perception, mood, and cognition via 5-HT2A receptor activation.

ROUTE / DOSAGE
LOW25mcg
STANDARD75-150mcg
HIGH300mcg+
Note: Most common route; typically on blotter paper or in liquid form
CYCLE
Max 1x p/w 2+ weeks between doses due to rapid tolerance
BIOAVAILABILITY
~71% sublingual high oral
ACTIVE DURATION
8-12h (subjective)
STORAGE
Room temperature dry away from light protect from moisture and heat
HALF-LIFE
3-5h (plasma)
DURATION BREAKDOWN
Total8-12 hours
Onset30-90 min
Come up45-90 min
Peak2-5 hours
Offset3-5 hours
After effects2-6 hours
Duration varies by route, dose, and individual. Source: community reports.
§ 01 — EFFECTS
8 documented
Visual and auditory hallucinations
Altered perception of time and space
Synesthesia
Mystical or spiritual experiences
Enhanced emotional empathy and openness
Derealization and depersonalization
Increased suggestibility
Elevated mood and bliss
§ 02 — RISKS
Psychological distress including anxiety, paranoia, and panic reactions during acute effects
Risk of psychotic episodes in vulnerable individuals, particularly those with schizophrenia spectrum disorders
Persistent perceptual changes (HPPD) in some users
Impaired judgment leading to dangerous behavior during intoxication
Flashback phenomena weeks or months after use
Rapid tolerance development with frequent use
§ 03 — INTERACTIONS
No interaction with your stack
VIEW STACK
CAUTION
Cannabis
Stimulants
AVOID · DANGEROUS
Lithium
Tramadol
Deliriants
Tricyclic antidepressants
Ritonavir
§ 04 — SCIENCE

Modern clinical research has shown that LSD in controlled settings induces bliss, synesthesia, derealization, and mystical experiences mediated by the 5-HT2A receptor. LSD increases feelings of closeness, openness, and trust while impairing recognition of negative emotional expressions. In patients with anxiety associated with life-threatening disease, anxiety was reduced for 2 months after two doses. LSD is physiologically safe with low toxicity and no complications observed in medical settings. However, therapeutic value remains to be confirmed in larger controlled trials, and most evidence comes from small pilot studies. Information about LSD pharmacokinetics in humans is limited and more research is needed.

§ 06 — SOURCES
[1]
Modern Clinical Research on LSD
pubmed.ncbi.nlm.nih.gov ↗
[2]
LSD (Clin Toxicol 1979)
pubmed.ncbi.nlm.nih.gov ↗
[3]
LSD: 1967
pubmed.ncbi.nlm.nih.gov ↗
[4]
Metabolism of lysergic acid diethylamide (LSD): an update
pubmed.ncbi.nlm.nih.gov ↗
[5]
The LSD Controversy
pubmed.ncbi.nlm.nih.gov ↗
[6]
LSD Intoxication
pubmed.ncbi.nlm.nih.gov ↗
[7]
The Efficacy of LSD in the Treatment of Alcoholism
pubmed.ncbi.nlm.nih.gov ↗
[8]
Dark Classics in Chemical Neuroscience: Lysergic Acid Diethylamide (LSD)
pubmed.ncbi.nlm.nih.gov ↗
[9]
PsychonautWiki - LSD
psychonautwiki.org ↗
Disclaimer. Protokol.wiki is an informational reference. Nothing on this site is medical advice. Compounds listed may be unapproved, unregulated, or illegal in your jurisdiction. Consult a licensed physician before use. Data compiled from peer-reviewed literature.
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