KANNA

LOW RISK

Supplements / Adaptogen

BEST FOR:Mood●●●●●●○○○○6/10

KANNA · SCELETIUM TORTUOSUM · KOUGOED · MESEMBRYANTHEMUM TORTUOSUM · CANNA · SCELETIUM

AdaptogenSerotonergicMoodSouth AfricanHerbal SupplementAnxiolytic

South African succulent with serotonergic and PDE4-inhibiting alkaloids used traditionally for mood, anxiety, and stress relief.

— QUICK REFERENCE

ROUTE / DOSAGE

LOW50mg

STANDARD100-200mg

HIGH300mg+

Note: Standardized extract; take on empty stomach for better absorption

CYCLE

Occasional use recommended avoid daily use to prevent tolerance

BIOAVAILABILITY

Low oral (~3-5%) higher sublingual and intranasal

ACTIVE DURATION

2-6h (subjective)

STORAGE

Cool dry place away from direct sunlight sealed container

HALF-LIFE

2-4h (plasma)

DURATION BREAKDOWN

Total2-6h

Onset30min-2h

Come up30-60 min

Peak1-2h

Offset1-2h

After effects1-3h

Duration varies by route, dose, and individual. Source: community reports.

§ 01 — EFFECTS

6 documented

Mood elevation

Anxiety reduction

Stress relief

Mild stimulation

Relaxation

Enhanced sociability

§ 02 — RISKS

Serotonin syndrome risk when combined with SSRIs, MAOIs, or other serotonergic agents

Headache at higher doses

Mild nausea or gastrointestinal discomfort

Possible sedation or drowsiness

Inconsistent alkaloid content in unregulated supplement products

§ 03 — INTERACTIONS

Interaction data not yet available for this compound.

§ 04 — SCIENCE

Sceletium tortuosum has a long history of traditional use by San and Khoikhoi peoples of South Africa for mood, stress, and social purposes. In vitro and animal studies confirm serotonin reuptake inhibition and PDE4 inhibition as primary pharmacological actions. A limited number of small human studies suggest reduced anxiety and improved mood, but large-scale randomized controlled trials are absent. Evidence for individual alkaloid contributions, optimal dosing, and long-term safety remains preliminary.

§ 06 — SOURCES

[1]

A Chewable Cure Kanna: Biological and Pharmaceutical Properties of Sceletium tortuosum

pubmed.ncbi.nlm.nih.gov ↗

Disclaimer. Protokol.wiki is an informational reference. Nothing on this site is medical advice. Compounds listed may be unapproved, unregulated, or illegal in your jurisdiction. Consult a licensed physician before use. Data compiled from peer-reviewed literature.

METHODOLOGYCONTRIBUTECONTACT