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COMPOUNDS / PSYCHEDELIC / FLY AGARIC
PSYCHEDELIC

FLY AGARIC

HIGH RISK
BEST FOR:Sleep●●●○○○○○○○3/10
AMANITA MUSCARIA · FLY AGARIC · FLY AMANITA · AMANITA · SOMA · FLIEGENPILZ · MUKHOMOR
EntheogenGABAergicMushroomSiberianHallucinogenSedative

Psychoactive mushroom containing muscimol and ibotenic acid, producing sedative-hallucinogenic effects via GABA-A agonism

ROUTE / DOSAGE
LOW1-3g
STANDARD5-10g
HIGH15g+
Note: Dried caps only; potency varies enormously by specimen and preparation. Decarboxylation (drying/heating) converts ibotenic acid to muscimol, reducing toxicity
CYCLE
Not recommended for regular use allow 1-2 weeks between experiences
BIOAVAILABILITY
Variable muscimol oral bioavailability estimated 10-20% ibotenic acid partially converts to muscimol via decarboxylation during drying or heating
ACTIVE DURATION
4-8h (subjective)
STORAGE
Dried mushroom material: store in airtight container cool dry away from light. Potency degrades over time
HALF-LIFE
2-3h (muscimol) (plasma)
DURATION BREAKDOWN
Total6-12 hours
Onset30min-2h
Come up1-2h
Peak2-3h
Offset2-4h
After effects4-8h
Duration varies by route, dose, and individual. Source: community reports.
§ 01 — EFFECTS
7 documented
Sedative-hallucinogenic state
Visual and auditory distortions
Dreamlike euphoria
Nausea and gastrointestinal distress
Muscle twitching and tremors
Altered perception of size and time
Confusion and disorientation
§ 02 — RISKS
Variable potency makes dosing unpredictable and dangerous
Paranoid hallucinatory psychosis reported in literature
Loss of consciousness and coma at high doses
Severe nausea, vomiting, and gastrointestinal distress
Neurotoxicity from ibotenic acid content
Bioaccumulation of heavy metals including mercury and cesium
§ 03 — INTERACTIONS
Interaction data not yet available for this compound.
§ 04 — SCIENCE

Amanita muscaria has been used as an entheogen in Siberian shamanic cultures for centuries. The primary psychoactive compounds are muscimol and ibotenic acid, with muscarine present in trace amounts. Muscimol is a high-affinity GABA-A agonist used extensively in neuroscience research as a radioligand. Clinical evidence for therapeutic use is minimal; however, recent preclinical research suggests potential in neuropathic pain relief. Potency varies dramatically between specimens, making dosing unpredictable. Case reports document severe adverse effects including paranoid psychosis and loss of consciousness. The biosynthetic pathway for ibotenic acid was only recently elucidated, starting from glutamate hydroxylation.

§ 06 — SOURCES
[1]
Classics in Chemical Neuroscience: Muscimol
pubmed.ncbi.nlm.nih.gov ↗
[2]
Fly agaric (Amanita muscaria) poisoning, case report and review
pubmed.ncbi.nlm.nih.gov ↗
[3]
Amanita muscaria (fly agaric): from a shamanistic hallucinogen to the search for acetylcholine
pubmed.ncbi.nlm.nih.gov ↗
[4]
Paranoid hallucinatory psychosis following intoxication with fly agaric
pubmed.ncbi.nlm.nih.gov ↗
[5]
Ibotenic Acid Biosynthesis in the Fly Agaric Is Initiated by Glutamate Hydroxylation
pubmed.ncbi.nlm.nih.gov ↗
[6]
PsychonautWiki - Amanita muscaria
psychonautwiki.org ↗
Disclaimer. Protokol.wiki is an informational reference. Nothing on this site is medical advice. Compounds listed may be unapproved, unregulated, or illegal in your jurisdiction. Consult a licensed physician before use. Data compiled from peer-reviewed literature.
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