COMPOUNDS / PAIN & ANTI-INFLAMMATORY / GABAPENTIN
PAIN & ANTI-INFLAMMATORY
GABAPENTIN
MEDIUM RISK
Medications / Pain & Anti-inflammatory
BEST FOR:Neuropathic Pain●●●●●●○○○○6/10
GABAPENTIN · NEURONTIN · GABA · GBP · 1-(AMINOMETHYL)CYCLOHEXANEACETIC ACID
AnticonvulsantNeuropathic PainCalcium Channel BlockerGABAergicPrescription
Anticonvulsant used for neuropathic pain and as an adjunct analgesic; acts on voltage-gated calcium channels.
— QUICK REFERENCE
ROUTE / DOSAGE
LOW100-600mg
STANDARD900-1500mg
HIGH2400mg+
Note: Bioavailability decreases with increasing dose due to saturable absorption; titrate slowly
CYCLE
Divided doses 3x daily
taper gradually to discontinue
BIOAVAILABILITY
27-60% oral (decreases with increasing dose)
ACTIVE DURATION
6-8h (subjective)
STORAGE
Room temperature (20-25°C)
dry place
away from light and moisture
HALF-LIFE
5-7h (plasma)
DURATION BREAKDOWN
Total6-10h
Onset30min-2h
Come up1-2h
Peak2-4h
Offset2-4h
After effects2-6h
Duration varies by route, dose, and individual. Source: community reports.
§ 01 — EFFECTS
7 documented
Reduces neuropathic pain
Decreases seizure frequency
Sedation and drowsiness
Dizziness and ataxia
Anxiolytic effects
Reduces postoperative opioid requirements
Mild euphoria at higher doses
§ 02 — RISKS
Respiratory depression, especially when combined with opioids or other CNS depressants
Suicidal ideation and behavioral changes reported
Ataxia, myoclonus, and encephalopathy at higher doses
Misuse and dependence potential with recreational use
Peripheral edema and weight gain
Withdrawal seizures on abrupt discontinuation
§ 03 — INTERACTIONS
No interaction with your stack
VIEW STACK
AVOID · DANGEROUS
Opioids
Depressants
§ 04 — SCIENCE
Gabapentin is a first-line agent for neuropathic pain with FDA approval for postherpetic neuralgia and partial seizures. Clinical efficacy rates are modest, and some reviews question whether net benefits outweigh harms in certain populations. Evidence supports use for menopausal vasomotor symptoms and perioperative opioid sparing, though pediatric perioperative data are insufficient for routine use. Atypical side effects including myoclonus, encephalopathy, and respiratory depression are increasingly recognized. Pharmacokinetics are nonlinear due to saturable oral absorption, making dose-response less predictable than pregabalin.
§ 06 — SOURCES
[6]
Gabapentin for the treatment of hot flushes in menopause: a meta-analysis
pubmed.ncbi.nlm.nih.gov ↗Disclaimer. Protokol.wiki is an informational reference. Nothing on this site is medical advice. Compounds listed may be unapproved, unregulated, or illegal in your jurisdiction. Consult a licensed physician before use. Data compiled from peer-reviewed literature.
METHODOLOGYCONTRIBUTECONTACT