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COMPOUNDS / LONGEVITY / DIHYDROMYRICETIN
LONGEVITY

DIHYDROMYRICETIN

LOW RISK
BEST FOR:Liver Health●●●●●●●○○○7/10
DIHYDROMYRICETIN · DHM · DMY · AMPELOPSIN · AMPELOPTIN · 3,3',4',5,5',7-HEXAHYDROXYFLAVANONE
FlavonoidAntioxidantHepatoprotectiveSenolyticTraditional Chinese Medicine

Natural flavonoid from Ampelopsis grossedentata with antioxidant, hepatoprotective, senotherapeutic, and anti-inflammatory properties.

ROUTE / DOSAGE
LOW150mg
STANDARD300-600mg
HIGH1000mg+
Note: Typically taken with food; traditional use as tea from Ampelopsis grossedentata leaves
CYCLE
Daily use acceptable no strict cycling required
BIOAVAILABILITY
Low oral bioavailability (~10-20%)
ACTIVE DURATION
4-8h (subjective)
STORAGE
Room temperature dry away from light
HALF-LIFE
4-6 hours (plasma)
DURATION BREAKDOWN
Total6-10 hours
Onset1-2 hours
Come up30-60 min
Peak2-4 hours
Offset2-4 hours
After effects2-6 hours
Duration varies by route, dose, and individual. Source: community reports.
§ 01 — EFFECTS
6 documented
Hepatoprotective
Antioxidant
Anti-inflammatory
Senolytic
Insulin sensitizing
Neuroprotective
§ 02 — RISKS
Low overall toxicity profile in animal studies
Possible drug-drug interactions via metabolic enzyme modulation
Theoretical risk of hypoglycemia in diabetic patients on glucose-lowering medications
Limited human safety data
§ 03 — INTERACTIONS
Interaction data not yet available for this compound.
§ 04 — SCIENCE

DHM has demonstrated hepatoprotective effects against alcohol-induced liver injury and nonalcoholic fatty liver disease in rodent models, improving liver regeneration via the miR-155-5p/SIRT1/VDAC1 pathway. It shows senotherapeutic potential by targeting senescent cells through PRDX2, alleviating age-related physiological decline in mice and improving Alzheimer's disease outcomes. Anti-inflammatory and antioxidant effects have been documented in colitis and cerebral ischemia-reperfusion injury models. However, clinical investigations remain scarce, with most evidence coming from in vitro and animal studies.

§ 06 — SOURCES
[1]
PubMed PMID 37643278
pubmed.ncbi.nlm.nih.gov ↗
[2]
PubMed PMID 38532480
pubmed.ncbi.nlm.nih.gov ↗
[3]
PubMed PMID 34273490
pubmed.ncbi.nlm.nih.gov ↗
[4]
PubMed PMID 36118165
pubmed.ncbi.nlm.nih.gov ↗
[5]
PubMed PMID 41792133
pubmed.ncbi.nlm.nih.gov ↗
[6]
PubMed PMID 39986231
pubmed.ncbi.nlm.nih.gov ↗
[7]
PubMed PMID 33776577
pubmed.ncbi.nlm.nih.gov ↗
[8]
PubMed PMID 37732125
pubmed.ncbi.nlm.nih.gov ↗
Disclaimer. Protokol.wiki is an informational reference. Nothing on this site is medical advice. Compounds listed may be unapproved, unregulated, or illegal in your jurisdiction. Consult a licensed physician before use. Data compiled from peer-reviewed literature.
METHODOLOGYCONTRIBUTECONTACT