SUPERDROL

Methasterone was marketed as an over-the-counter supplement before being identified as a potent anabolic steroid and subsequently scheduled. Case reports document severe cholestatic hepatitis, renal failure, and IgA nephropathy associated with its use. Metabolism studies in humanized mouse models and in vitro liver S9 fractions have identified multiple hydroxylated and 3-keto reduced metabolites, as well as phase II sulfation products, aiding anti-doping detection. No controlled human clinical trials exist; evidence of efficacy is limited to anecdotal reports and animal data. The hepatotoxicity profile is among the most severe of oral steroids, with multiple published cases of acute liver injury requiring hospitalization.