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COMPOUNDS / STEROID / METHANDROSTENOLONE
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METHANDROSTENOLONE

HIGH RISK
BEST FOR:Bulking●●●●●●●●○○8/10
METHANDROSTENOLONE · METHANDIENONE · DIANABOL · DIANABOL · DBOL · METANDIENONE · 17Α-METHYL-Δ1-TESTOSTERONE · CIBA 16201
Anabolic SteroidOral 17-AlphaBulkingHepatotoxicAndrogenicPerformance Enhancement

Oral 17α-alkylated anabolic-androgenic steroid (Dianabol) used for rapid muscle mass and strength gains.

ROUTE / DOSAGE
LOW15mg
STANDARD20-40mg
HIGH50mg+
Note: Split into 2-3 doses daily due to short half-life; 17α-alkylated hepatotoxicity limits cycle length to 4-6 weeks
CYCLE
4-6 weeks max no long-term or daily standalone use due to hepatotoxicity
BIOAVAILABILITY
~50-60% oral (17α-alkylated) IM absorption near-complete but still hepatically stressful
ACTIVE DURATION
3-5h (subjective)
STORAGE
Room temperature dry away from light keep tablets sealed
HALF-LIFE
3-6 hours (plasma)
DURATION BREAKDOWN
Total4-6 hours
Onset30-60 min
Come up1-2 hours
Peak2-3 hours
Offset2-3 hours
After effects12-24 hours
Duration varies by route, dose, and individual. Source: community reports.
§ 01 — EFFECTS
7 documented
Rapid muscle mass increase
Significant strength gains
Water retention and bloating
Increased nitrogen retention
Elevated blood pressure
Mood elevation and aggression
Elevated liver enzymes
§ 02 — RISKS
Severe hepatotoxicity including cholestatic hepatitis and liver tumors (17α-alkylation)
Cardiovascular strain: hypertension, dyslipidemia (low HDL, high LDL), left ventricular hypertrophy
Suppression of endogenous testosterone production and testicular atrophy
Gynecomastia via aromatization to methylestradiol
Androgenic effects: acne, male pattern baldness, virilization in women
Psychological effects including mood swings, aggression, and dependence
§ 03 — INTERACTIONS
Interaction data not yet available for this compound.
§ 04 — SCIENCE

Methandrostenolone was developed in the 1950s and became one of the most widely used oral anabolic steroids, originally prescribed for osteoporosis, rheumatic diseases, and catabolic states. Studies in castrated rats demonstrated thymolytic effects and specific androgen-receptor binding in thymic tissue, confirming its androgenic mechanism. Metabolism studies identified multiple hydroxylated metabolites and a 6β-hydroxylation pathway, with long-term high-dose use leading to detectable unmetabolized drug in urine. Evidence for performance enhancement is largely anecdotal and from illicit use; controlled clinical trials for athletic performance are lacking, and the drug's hepatotoxicity has limited its legitimate medical use.

§ 06 — SOURCES
[1]
PubMed PMID 14237023
pubmed.ncbi.nlm.nih.gov ↗
[2]
PubMed PMID 2214760 - Methandrostenolone metabolism in humans
pubmed.ncbi.nlm.nih.gov ↗
[3]
PubMed PMID 14173048 - Methandrostenolone, an oral anabolic agent
pubmed.ncbi.nlm.nih.gov ↗
[4]
PubMed PMID 2378961 - Thymolytic effects of methandrostenolone
pubmed.ncbi.nlm.nih.gov ↗
[5]
PubMed PMID 14461022 - Methandrostenolone in rheumatic diseases and osteoporosis
pubmed.ncbi.nlm.nih.gov ↗
[6]
PubMed PMID 4791949 - Dermatomyositis
pubmed.ncbi.nlm.nih.gov ↗
[7]
PubMed PMID 2723001 - Determination of methandrostenolone and metabolites in equine plasma
pubmed.ncbi.nlm.nih.gov ↗
[8]
PubMed PMID 14259901 - Hormone-sulphatase relationships
pubmed.ncbi.nlm.nih.gov ↗
Disclaimer. Protokol.wiki is an informational reference. Nothing on this site is medical advice. Compounds listed may be unapproved, unregulated, or illegal in your jurisdiction. Consult a licensed physician before use. Data compiled from peer-reviewed literature.
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