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COMPOUNDS / AMINO ACID / TYROSINE
AMINO ACID

TYROSINE

LOW RISK
BEST FOR:Stress Cognition●●●●●●○○○○6/10
TYROSINE · L-TYROSINE · L-2-AMINO-3-(4-HYDROXYPHENYL)PROPANOIC ACID · TYR · N-ACETYL-L-TYROSINE
Amino AcidCatecholamine PrecursorNootropicStress ResilienceDopamine Support

Amino acid precursor to dopamine, norepinephrine, and epinephrine; may buffer cognitive decline under acute stress.

ROUTE / DOSAGE
LOW500-1000mg
STANDARD1000-2000mg
HIGH2000-3000mg+
Note: Take on an empty stomach for better absorption; avoid taking with other large neutral amino acids that compete for transport
CYCLE
Daily use acceptable cycling not typically required
BIOAVAILABILITY
~30-40% oral (competes with other large neutral amino acids for transport)
ACTIVE DURATION
2-4h (subjective)
STORAGE
Room temperature dry away from light and moisture
HALF-LIFE
~2h (plasma)
DURATION BREAKDOWN
Total3-5 hours
Onset30-90 min
Come up30-60 min
Peak1-2 hours
Offset1-2 hours
After effects1-3 hours
Duration varies by route, dose, and individual. Source: community reports.
§ 01 — EFFECTS
6 documented
Improved working memory under stress
Faster information processing
Mild alertness increase
Catecholamine replenishment
Reduced stress-induced cognitive decline
Possible mild mood elevation
§ 02 — RISKS
GI discomfort or nausea at high doses
Potential interaction with MAOIs (hypertensive crisis risk)
May reduce absorption of other amino acids when taken simultaneously
Insomnia if taken late in day
Theoretical concern in hyperthyroidism due to thyroxine precursor role
§ 03 — INTERACTIONS
No interaction with your stack
VIEW STACK
CAUTION
Alcohol
MXE
Dissociatives
AVOID · DANGEROUS
25x-NBOMe
25x-NBOH
Tramadol
MAOIs
DXM
MDMA
Stimulants
§ 04 — SCIENCE

A 2015 systematic review of 15 studies found that acute tyrosine loading counteracted decrements in working memory and information processing induced by demanding conditions such as extreme weather or high cognitive load, but showed no significant effects on exercise performance. Animal research demonstrates that tyrosine accelerates catecholamine synthesis and increases blood pressure in hemorrhaged hypotensive rats, an effect blocked by carbidopa. Evidence for benefit in healthy, non-stressed individuals is weak; most studies involve single acute doses in small samples. Long-term chronic supplementation studies are lacking.

§ 06 — SOURCES
[1]
Behavioral and cognitive effects of tyrosine intake in healthy human adults (PMID 25797188)
pubmed.ncbi.nlm.nih.gov ↗
[2]
Tyrosine accelerates catecholamine synthesis in hemorrhaged hypotensive rats (PMID 3995291)
pubmed.ncbi.nlm.nih.gov ↗
[3]
PsychonautWiki - Tyrosine
psychonautwiki.org ↗
Disclaimer. Protokol.wiki is an informational reference. Nothing on this site is medical advice. Compounds listed may be unapproved, unregulated, or illegal in your jurisdiction. Consult a licensed physician before use. Data compiled from peer-reviewed literature.
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