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COMPOUNDS / AMINO ACID / DLPA
AMINO ACID

DLPA

LOW RISK
BEST FOR:Mood●●●●●○○○○○5/10
DL-PHENYLALANINE · DLPA · D,L-PHENYLALANINE · DL-PHENYLALANINE · DLPA SUPPLEMENT
Amino AcidMoodPain ReliefSupplementCatecholamine Precursor

A racemic mixture of D- and L-phenylalanine used for mood support and mild pain relief via endorphin preservation and catecholamine synthesis.

ROUTE / DOSAGE
LOW500mg
STANDARD500-1500mg
HIGH2000mg+
Note: Take on empty stomach for better absorption; avoid taking with protein meals
CYCLE
Take on empty stomach avoid late evening dosing cycle 2 weeks on / 1 week off
BIOAVAILABILITY
~50% oral
ACTIVE DURATION
4-6h (subjective)
STORAGE
Room temperature dry away from light keep container tightly sealed
HALF-LIFE
2-3h (plasma)
DURATION BREAKDOWN
Total4-6 hours
Onset30min-2h
Come up30-60 min
Peak1-2 hours
Offset1-2 hours
After effects2-4 hours
Duration varies by route, dose, and individual. Source: community reports.
§ 01 — EFFECTS
6 documented
Mood elevation
Mild analgesia
Increased alertness
Mild stimulation
Reduced physical discomfort
Enhanced motivation
§ 02 — RISKS
Contraindicated in phenylketonuria (PKU) due to phenylalanine content
May cause hypertension at high doses
Dangerous interaction with MAOIs due to tyramine pressor effect
May trigger anxiety or jitteriness in susceptible individuals
Gastrointestinal upset at high doses
§ 03 — INTERACTIONS
Interaction data not yet available for this compound.
§ 04 — SCIENCE

DLPA has been studied since the 1970s for mild pain conditions and depression, with some small clinical trials suggesting benefit for chronic pain and mood. The D-isomer's enkephalinase inhibition is supported by animal data but human evidence remains limited and mixed. The L-isomer's role as a catecholamine precursor is biochemically well established, though clinical outcomes for depression are inconsistent. Overall, evidence is preliminary and insufficient for strong therapeutic claims; most studies are small and methodologically limited.

§ 06 — SOURCES
[1]
PubMed PMID 32773365
pubmed.ncbi.nlm.nih.gov ↗
[2]
PubMed PMID 38850073
pubmed.ncbi.nlm.nih.gov ↗
[3]
PubMed PMID 31357517
pubmed.ncbi.nlm.nih.gov ↗
[4]
PubMed PMID 22634043
pubmed.ncbi.nlm.nih.gov ↗
[5]
PubMed PMID 38778963
pubmed.ncbi.nlm.nih.gov ↗
[6]
PubMed PMID 29343090
pubmed.ncbi.nlm.nih.gov ↗
[7]
PubMed PMID 23928896
pubmed.ncbi.nlm.nih.gov ↗
[8]
PubMed PMID 36089068
pubmed.ncbi.nlm.nih.gov ↗
Disclaimer. Protokol.wiki is an informational reference. Nothing on this site is medical advice. Compounds listed may be unapproved, unregulated, or illegal in your jurisdiction. Consult a licensed physician before use. Data compiled from peer-reviewed literature.
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