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COMPOUNDS / STEROID / TESTOSTERONE CYPIONATE
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TESTOSTERONE CYPIONATE

HIGH RISK
BEST FOR:TRT●●●●●●●●○○8/10
TESTOSTERONE CYPIONATE · DEPO-TESTOSTERONE · TESTOSTERONE CYP · TC · TESTOSTERONE CYCLOPENTYLPROPIONATE
Testosterone EsterTRTAndrogenAnabolic SteroidDepot Injection

Long-acting testosterone ester injected weekly or biweekly for testosterone replacement therapy.

ROUTE / DOSAGE
LOW50mg
STANDARD100mg
HIGH200mg
Note: Weekly subcutaneous injection provides more stable serum levels with lower peak-to-trough ratio
CYCLE
Every 1-2 weeks IM weekly subq preferred for stable levels
BIOAVAILABILITY
~70% IM depot negligible oral due to first-pass metabolism
ACTIVE DURATION
2-4 weeks (subjective)
STORAGE
Room temperature 20-25°C protect from light and freezing do not refrigerate
HALF-LIFE
~8 days (plasma)
DURATION BREAKDOWN
Total2-4 weeks per injection cycle
Onset24-48h
Come up2-5 days
Peak24-72h post-injection
Offset1-2 weeks
After effects2-4 weeks (return to baseline after cessation)
Duration varies by route, dose, and individual. Source: community reports.
§ 01 — EFFECTS
8 documented
Increased serum testosterone
Improved libido and erectile function
Increased muscle mass and strength
Elevated hematocrit and hemoglobin
Suppression of LH and FSH
Aromatization to estradiol
Mood improvement
Reduced spermatogenesis
§ 02 — RISKS
Erythrocytosis/polycythemia requiring phlebotomy or dose reduction
Suppression of endogenous testosterone and spermatogenesis (potentially irreversible)
Cardiac hypertrophy and left ventricular remodeling at supraphysiological doses
Gynecomastia via aromatization to estradiol
Injection site reactions including delayed hypersensitivity
Increased risk of venous thromboembolism and cardiovascular events
§ 03 — INTERACTIONS
Interaction data not yet available for this compound.
§ 04 — SCIENCE

Testosterone cypionate is well-established for treatment of male hypogonadism, with IM 100-200mg every 1-2 weeks being the standard regimen. A PK/PD model (PMID 29436172) showed dose-dependent suppression of LH and spermatogenesis, with 250mg and 500mg weekly causing more severe and prolonged suppression. IM administration causes supraphysiological peaks associated with increased hematocrit, estradiol, and PSA compared to subcutaneous delivery (PMID 34694927). Dose reduction to 100mg biweekly preserved therapeutic testosterone levels while modestly reducing hematocrit in trans men with erythrocytosis (PMID 41052128). Animal studies at supraphysiological doses show cardiac morphology changes including left ventricular lumen enlargement (PMID 30772437). Evidence for non-TRT performance or anti-aging use remains weak and controversial.

§ 06 — SOURCES
[1]
Beyond testosterone cypionate: evidence behind the use of nandrolone in male health and wellness
pubmed.ncbi.nlm.nih.gov ↗
[2]
Testosterone - Drugs and Lactation Database (LactMed)
pubmed.ncbi.nlm.nih.gov ↗
[3]
Effect of 100 mg of testosterone cypionate in trans men with erythrocytosis: a randomized controlled pilot study
pubmed.ncbi.nlm.nih.gov ↗
[4]
Delayed hypersensitivity reaction to testosterone cypionate injections
pubmed.ncbi.nlm.nih.gov ↗
[5]
Effect of testosterone cypionate and stanozolol on the heart of young trained mice: A morphometric study
pubmed.ncbi.nlm.nih.gov ↗
[6]
Comparison of Hematocrit Change in Testosterone-deficient Men Treated With Intranasal Testosterone Gel vs Intramuscular Testosterone Cypionate
pubmed.ncbi.nlm.nih.gov ↗
[7]
Comparison of Outcomes for Hypogonadal Men Treated with Intramuscular Testosterone Cypionate versus Subcutaneous Testosterone Enanthate
pubmed.ncbi.nlm.nih.gov ↗
[8]
Population Pharmacokinetic/Pharmacodynamic Modeling of Depot Testosterone Cypionate in Healthy Male Subjects
pubmed.ncbi.nlm.nih.gov ↗
Disclaimer. Protokol.wiki is an informational reference. Nothing on this site is medical advice. Compounds listed may be unapproved, unregulated, or illegal in your jurisdiction. Consult a licensed physician before use. Data compiled from peer-reviewed literature.
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