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COMPOUNDS / STEROID / NANDROLONE DECANOATE
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NANDROLONE DECANOATE

HIGH RISK
BEST FOR:Muscle Mass●●●●○○○○○○4/10
NANDROLONE DECANOATE · DECA-DURABOLIN · DECA · NANDROLONE DECANOATE · 19-NORTESTOSTERONE DECANOATE · ND · DECANOATE DE NANDROLONE
Anabolic Steroid19-NortestosteroneInjectableWADA BannedMuscle MassOsteoporosis

Long-acting injectable 19-nortestosterone anabolic steroid used clinically for osteoporosis and cachexia, widely abused for muscle growth.

ROUTE / DOSAGE
LOW50mg
STANDARD200-400mg
HIGH600mg+
Note: Less common than IM; slower release from subcutaneous tissue may alter pharmacokinetics
CYCLE
8-16 weeks 1-2x weekly injections
BIOAVAILABILITY
~100% IM
ACTIVE DURATION
2-3 weeks (subjective)
STORAGE
Room temperature (15-30°C) protect from light do not freeze
HALF-LIFE
6-12 days (plasma)
DURATION BREAKDOWN
Total2-3 weeks
Onset24-48h
Come up1-2 weeks
Peak1-2 weeks
Offset2-3 weeks
After effects3-4 weeks
Duration varies by route, dose, and individual. Source: community reports.
§ 01 — EFFECTS
8 documented
Increased lean soft tissue mass
Enhanced nitrogen retention and protein synthesis
Increased bone mineral content at some sites
Reduced vertebral pain and improved spinal mobility
Suppression of endogenous testosterone
Virilization in female users
Altered mood and aggression
Impaired recognition memory with long-term use
§ 02 — RISKS
Endocrine disruption: virilization, gynecomastia, infertility, dyslipidemia, hormonal disorders
Cardiovascular dysfunction: vascular damage, coagulation disorders, hypertension, arteriosclerosis
Psychiatric and mood disorders: aggression, anxiety, sleep disorders
Suppression of endogenous testosterone production and testicular atrophy
Gastrointestinal dysmotility and morphometric changes to intestinal mucosa
Cognitive impairment including recognition memory deficits with long-term supraphysiological use
§ 03 — INTERACTIONS
Interaction data not yet available for this compound.
§ 04 — SCIENCE

A 2026 systematic review and meta-analysis of 20 RCTs found nandrolone decanoate modestly increased lean soft tissue (1.59 kg) but did not improve handgrip strength, knee extension strength, or consistently improve bone mineral density. Clinical use in osteoporosis (50 mg every 3-4 weeks) showed increased bone mineral content and reduced vertebral pain, but virilization occurred in ~50% of female patients. Animal studies demonstrate ND impairs recognition memory, alters stress hormone levels, and affects neurotransmitter systems in brain region-dependent patterns. A systematic review of 148 studies found endocrine effects (42%), cardiovascular dysfunctions (14%), skin disorders (12%), and psychiatric disorders (9%) as the most common adverse effects from abuse. The GRADE assessment displayed low certainty of evidence, and the meta-analysis concluded findings do not support routine clinical use for musculoskeletal health.

§ 06 — SOURCES
[1]
Nandrolone Decanoate: Use, Abuse and Side Effects (PMID 33187340)
pubmed.ncbi.nlm.nih.gov ↗
[2]
Nandrolone decanoate: new therapeutic option for telomeropathies? (PMID 36815395)
pubmed.ncbi.nlm.nih.gov ↗
[3]
Nandrolone decanoate: pharmacological properties and therapeutic use in osteoporosis (PMID 8846659)
pubmed.ncbi.nlm.nih.gov ↗
[4]
The impact of nandrolone decanoate on the central nervous system (PMID 26074747)
pubmed.ncbi.nlm.nih.gov ↗
[5]
Effects of Nandrolone Decanoate on Muscle Strength, Body Composition and Bone Density: A Systematic Review and Meta-Analysis (PMID 41936385)
pubmed.ncbi.nlm.nih.gov ↗
[6]
Nandrolone decanoate impairs gastrointestinal motility and duodenal morphometry in moderately exercised rats (PMID 38958368)
pubmed.ncbi.nlm.nih.gov ↗
[7]
Nandrolone decanoate and testosterone undecanoate differently affect stress hormones, neurotransmitter systems, and general activity in the male rat (PMID 35738337)
pubmed.ncbi.nlm.nih.gov ↗
[8]
The decanoate esters of nandrolone, testosterone, and trenbolone induce steroid specific memory impairment and somatic effects in the male rat (PMID 38368844)
pubmed.ncbi.nlm.nih.gov ↗
Disclaimer. Protokol.wiki is an informational reference. Nothing on this site is medical advice. Compounds listed may be unapproved, unregulated, or illegal in your jurisdiction. Consult a licensed physician before use. Data compiled from peer-reviewed literature.
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