MAGNESIUM GLYCINATE

A randomized crossover trial in ileal resection patients demonstrated that magnesium diglycinate is absorbed partly intact via a dipeptide transport pathway, with earlier peak enrichment and better tolerability than magnesium oxide, particularly in patients with the greatest absorption impairment. A 12-week RCT found that combined magnesium glycinate (360 mg elemental Mg) and vitamin D supplementation significantly increased serum 25-hydroxyvitamin D concentrations compared to vitamin D alone, and reduced systolic blood pressure in participants with baseline hypertension. However, the same trial found no significant effects on bone turnover markers or glycemic indices. A case report showed magnesium glycinate successfully corrected refractory hypomagnesemia in a post-bariatric surgery patient with combined malabsorption and renal magnesium wasting. An 8-week rat study raised concerns that long-term magnesium administration may initiate apoptotic cascades in brain tissue, though histological evaluation showed no pathological findings. Evidence for cognitive or sleep benefits in healthy populations remains limited.