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COMPOUNDS / EMPATHOGEN / 3-MMC
EMPATHOGEN

3-MMC

HIGH RISK
BEST FOR:Social●●●○○○○○○○3/10
3-MMC · 3-METHYLMETHCATHINONE · METAPHEDRONE · 3-MEPHEDRONE
Synthetic CathinoneStimulantEmpathogenNPSResearch Chemical

Synthetic cathinone stimulant with empathogenic effects, closely related to mephedrone (4-MMC), associated with rising harm and dependence.

ROUTE / DOSAGE
LOW50mg
STANDARD150-250mg
HIGH350mg+
Note: Slower onset but longer duration than intranasal
CYCLE
Max 2x per week no daily use
BIOAVAILABILITY
~50-70% oral ~60-80% intranasal 100% IV ~60-80% rectal
ACTIVE DURATION
2-5h (subjective)
STORAGE
Room temperature dry away from light store as hydrochloride salt in sealed container
HALF-LIFE
2-4h (plasma)
DURATION BREAKDOWN
Total2-5 hours
Onset5-30 min
Come up10-60 min
Peak1-2 hours
Offset1-2 hours
After effects2-6 hours
Duration varies by route, dose, and individual. Source: community reports.
§ 01 — EFFECTS
8 documented
Euphoria and elevated mood
Increased energy and stimulation
Enhanced sociability and empathy
Mild psychedelic and dissociative effects at higher doses
Decreased appetite
Increased heart rate and blood pressure
Short duration leading to compulsive re-dosing
Craving and wanting
§ 02 — RISKS
Severe cardiovascular toxicity including hypertension and cardiac arrest
Increasing dependence and problematic use patterns with compulsive re-dosing
Sympathomimetic toxicity: tachycardia, agitation, hyperthermia
Variable purity (21-98%) and adulteration with other NPS in street samples
Polydrug use amplifies risk of adverse outcomes
Limited clinical safety data with most evidence from case reports
§ 03 — INTERACTIONS
No interaction with your stack
VIEW STACK
CAUTION
Alcohol
MXE
Dissociatives
AVOID · DANGEROUS
25x-NBOMe
25x-NBOH
Tramadol
SNRIs
MAOIs
Serotonin releasers
SSRIs
5-HTP
DXM
MDMA
Stimulants
§ 04 — SCIENCE

3-MMC emerged as a replacement for mephedrone (4-MMC) and has become widespread, particularly among young nightlife users in Europe. A first-in-human controlled trial (25-100mg oral) found dose-dependent increases in heart rate, blood pressure, and subjective high, with enhancement of neurocognitive performance and transient ratings of liking and wanting. However, retrospective poisoning data from the Netherlands show increasing cases of moderate to severe toxicity including tachycardia, hypertension, agitation, and one nonfatal cardiac arrest. Treatment-seeking for problematic 3-MMC use rose tenfold in the Netherlands between 2021 and 2023. Evidence on long-term harms remains limited, with most toxicological data derived from case reports and user surveys rather than controlled studies.

§ 06 — SOURCES
[1]
The novel psychoactive substance 3-methylmethcathinone (3-MMC or metaphedrone): A review
pubmed.ncbi.nlm.nih.gov ↗
[2]
Appearance of 2-MMC and 3-MMC on the illicit drug market in the Netherlands: A systematic narrative review
pubmed.ncbi.nlm.nih.gov ↗
[3]
NPAideS: a drug-checking study among 3-methylmethcathinone (3-MMC) users
pubmed.ncbi.nlm.nih.gov ↗
[4]
3-Methylmethcathinone (3-MMC) Poisonings: Acute Clinical Toxicity and Time Trend Between 2013 and 2021 in the Netherlands
pubmed.ncbi.nlm.nih.gov ↗
[5]
Safety and cognitive pharmacodynamics following dose escalations with 3-methylmethcathinone (3-MMC): a first in human, designer drug study
pubmed.ncbi.nlm.nih.gov ↗
[6]
In vitro biotransformation of 3-methylmethcathinone (3-MMC) through incubation with human liver microsomes and cytosol
pubmed.ncbi.nlm.nih.gov ↗
[7]
Analytical Characterization of 3-MeO-PCP and 3-MMC in Seized Products and Biosamples
pubmed.ncbi.nlm.nih.gov ↗
[8]
PsychonautWiki - 3-MMC
psychonautwiki.org ↗
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